Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain

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Name: Instructor: Course: Date: Article reviewed: Dorr, Alexander, et al. "Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain." The EMBO Journal 21.11 (2002): 2715-2723. The article, "Transcriptional synergy between Tat and PCAF is dependent on the binding of acetylated Tat to the PCAF bromodomain," by Dorr Alexander et al. seeks to test the probability of acetylated Tat’s interaction with a bromodomain. The research question is to address the acetylated Tat-PCAF interaction and a subsequent examination of “its relevance to the transcriptional activation process mediated by Tat” (Dorr et al. 2715). It is distinctly clear from the abstract that this is a very vital issue, concerning the essential role that the HIV Tat protein plays in the promotion of efficient viral transcripts elongation. The authors introduce the subject through citing the relevant literature regarding transactivator role played by the HIV Tat protein, who’s binding to the Tat-responsive element (TAR) would stimulate full-length HIV transcripts to be produced. The TAR/Tat axis is critical in determining the viral replication dynamics in cells that are infected. They infer to previous experiments that have uniquely highlighted the Tat role in this HIV transcription as a coordinative adaptor to other factors in the HIV promoter (Wei et al. 451-460). Another factor of essence is the transcriptional regulation role played by the reversible lysine residues acetylation. For them to test the probability of interaction between acetylated Tat and the bromodomain, the researchers examined various proteins containing bromodomain.

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