Rifampin

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Rifampin Student’s Name Institution Rifampin is a rifamycin antibiotic that used against bacterial pathogens. Examples of these pathogens include the Mycobacterium tuberculosis that causes tuberculosis, Hemophilus influenza that causes respiratory symptoms and Neisseria meningitides that cause meningitis and respiratory symptoms.The mechanism of action of rifampin is binding to the beta subunit of the DNA-dependent RNA polymerase in bacteria and therefore arrests RNA production and consequently protein synthesis. It is effective in tuberculosis since it can penetrate the body tissues to reach the bacteria and it is selective for the bacterial polymerase, sparing the human cells. Sanofi-Aventis is the company that produces rifampin under the brand names Rifadin and Rifadin IV. It is also produced in preparations that target the mycobacteria by taking advantage of combination medication that exerts their effects at different sites or through different mechanisms resulting in synergistic action. Under the brand name rifamate, the company produces rifampin and isoniazid as a combination medication. The company, Sanofi-Aventis, can be contacted through their website www.sanofi.us. Alternatively, the company can be reached through its address Sanofi-Aventis U.S. LLC, 55 Corporate Drive, Bridgewater, NJ 00807. They can also be reached by phone at (800)981-2491, Rifampicin is a rifamycin. This group of drugs acts by inhibiting the bacterial protein metabolism at the molecular level. They all prevent the synthesis of DNA-dependent RNA polymerase. They have a shared chemical structure of an ansa carbon chain derived from propionate and acetate with a seven-carbon

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